Built for Mary Perram, this house was once within an exclusive residential neighbourhood that included Jarvis Street to the west and Sherbourne Street to the east. Later occupied by Frederick Law, Secretary to the Lieutenant-Governors of Ontario, the building was purchased in 1923 by the Sisters of Service, a Roman Catholic women's order. Marking the changing neighbourhood, they operated this home as a hospice for immigrant women from 1923 to 1950. Used by Princess Margaret Hospital as an office and research facility in the 1970's, it is now again used as a hospice. The Mary Perram House blends Italianate and Gothic Revival features typical of its period, and stands in contrast to the later Romanesque Revival house next door. It was renovated and restored in 2005.