Eugene O'Keefe (1827-1913), was born in County Cork, Ireland, and immigrated to Canada with his father in 1832. In 1861 he acquired the Victoria Brewery at the corner of Gould and Victoria Streets. Later known as the O'Keefe Brewery it became the largest in Canada. He bought this house in 1879, making substantial alterations in 1889, and lived here until his death. A trustee of the Toronto General Hospital and benefactor to many Roman Catholic Institutions, in recognition of his many philanthropies, he was appointed Private Chamberlain to the Pope in 1909. In 1963, after a variety of uses, O'Keefe's home became a student residence for Ryerson Polytechnical Institute.