Sainte-Marie II
In the wake of the destructive Iroquois raids of early 1649 the Jesuits abandoned the mission of Sainte-Marie and joined several hundred Huron refugees here on Christian Island, which the Hurons called Gahoendoe and the French Ile-Saint-Joseph. They erected a second, fortified, Sainte-Marie in the summer of 1649. Severe famine and pestilence followed, and when Iroquois raiders reappeared in 1650 the Hurons were unable to resist. At the urging of the chiefs the mission was abandoned on 10 June 1650, and some 300 Hurons made their way with Father Paul Ragueneau to Quebéc.
Plaque via Alan L. Brown's site Ontario Plaques. Full page here.