Born in nearby Matilda township, Locke studied medicine at Queen's University and in Scotland. In 1908 he opened his medical office in this house. Interested in arthritis, which he believed was caused principally by fallen arches, he treated many arthritics in the following years by manual manipulation of their feet. Large numbers of his patients claimed to be cured or relieved by this method and his reputation spread across North America and overseas. From 1928 onwards thousands of the sick visited Dr. Locke in Williamsburg where he reportedly treated hundreds of persons daily. During the depression years this enormous influx brought significant prosperity to the region.