Knox College
Founded in 1844 by the Free Presbyterian Church as a seminary, Knox College was named in 1846 to honour Scottish reformer John Knox. After the 1861 union of Presbyterians, it remained as the only Presbyterian theological school in Toronto. This Gothic Revival structure, the college's fifth home, was designed by Toronto architects Smith and Gemmel in 1875. The college received its charter to confer degrees in theology in 1881 and affiliated with the University of Toronto in 1887. It moved to new premises on King's College Circle in 1915. This building has housed a series of occupants, including the Spadina Military Hospital. Connaught Laboratories, a world leader in the development and manufacture of vaccines, insulin and penicillin, purchased it in 1943 largely for penicillin production. The University of Toronto acquired the property in the 1970's.
Plaque via Alan L. Brown's site Toronto Plaques. Full page here.